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Propranolol – the drug that has antihypertensive, antiarrhythmic and antianginal effects.
Propranolol is used to treat coronary heart disease, cardiac arrhythmias, and some forms of hypertension (persistent increase in blood pressure).
In ischemic heart disease Propranolol reduces the frequency of angina attacks, increases exercise capacity, reduces the need for nitroglycerine. The drug is effective in angina at rest, but especially in angina. As antiarrhythmic drug Propranolol used for sinus and paroxysmal tachycardia (uchennyh the heart rate), arrhythmia, fibrillation and atrial flutter. The drug is indicated for patients with ventricular premature beats after myocardial infarction.
If sinus tachycardia is usually observed normalization of rhythm, including in cases of resistance (stability) to cardiac glycosides.
For hypertension Propranolol is prescribed mainly in the initial stages of the disease. The drug is most effective in young patients (under 40 years) with hyperdynamic type of blood circulation and elevated levels of renin. Lowering blood pressure is accompanied by a decrease in cardiac output due to deceleration of the heart rate and reduce stroke volume of the heart. Peripheral resistance (vascular resistance to the flow of blood) to moderately high. The drug does not cause orthostatic hypotension (drop in blood pressure when moving from horizontal to vertical position).
There is evidence of use in hypertension (moderate and severe) of propranolol in combination with alpha-blocker phentolamine by.